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allosteric inhibitionallosterische Inhibition (ger.)

  • Any inhibition of an enzyme by a negative allosteric effector. (Oxford Dict. of Biochemistry and Molecular Biol. 2008)

    In 1954, Novick and Szilard discovered that the synthesis of a tryptophan precursor […] was inhibited by tryptophan […]. The work of Umbarger [...] demonstrated that, in many pathways, an early enzyme is so constructed as to be strongly and specifically inhibited by the [...] endproduct […]. The most remarkable feature of the Novick-Szilard-Umbarger effect is that the inhibitor is not a steric analogue of the substrate. We propose therefore to designate this mechanism as ‘allosteric inhibition’.

    Monod, J. & Jacob, F. (1961). Teleonomic mechanism in cellular metabolism, growth, and differentiation. Cold Spring Harbor Symp. Quant. Biol. 26, 389-401: 391; cf. Monod, J., Changeux, J.-P. & Jacob, F. (1963). Allosteric proteins and cellular control systems. J. Mol. Biol. 6, 306-329.