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enzymeEnzym (ger.)

  • Any of the proteins produced by cells which catalyse specific biochemical reactions; formerly called (unorganized) ferment. (OED 2012)
    1878

    Alle bisher für das Eiweiss-zersetzende Enzym (das sog. Pankreatin) der Bauchspeicheldrüse gehaltenen Körper enthalten nun als Beimengung mindestens einen ganz indifferenten Eiweissstoff in reichlicher Menge

    Kühne, W. (1878). Ueber das Trypsin (Enzym des Pankreas). Verhandlungen des Naturhistorisch-medizinischen Vereins zu Heidelberg 1, 194-198: 195.

    1881

    I would suggest the desirability of adopting this term [Ger. enzym] into English, with a slight change of orthography, as “enzymes,” and also of coining from this root the cognate words which are requisite for clear and concise description.

    Roberts, W. (1881). On the estimation of amylolytic and proteolytic activity of pancreatic extracts. Proc. Royal Soc. 32, 145-161: 146.

References: Stoff, H. (2012). Wirkstoffe. Eine Wissenschaftsgeschichte der Hormone, Vitamine und Enzyme, 1920-1970.