Result of Your Query

A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Z

splicingSplicing (ger.)

  • To join together or insert (segments of DNA or RNA) so as to form new genetic combinations or alter a genetic structure. (American Heritage Dict. 2012)

    some type of crossover event could be used for splicing of variable and constant region genes at the DNA level

    Kabat, D. (1972). Gene selection in hemoglobin and in antibody-synthesizing cells. Science 175, 134-140: 139.


    We can think of no plausible mechanism that would explain the mutant specificity for such recombination, and we consider an explanation of splicing based on mRNA to be a remote possibility. Much more likely, we feel, is that splicing occurs at the level of polypeptide synthesis or between completed polypeptide chains.

    Apte, B.N. & Zipser, D. (1973). In vivo splicing of protein: one continuous polypeptide from two independently functioning operons. Proc. Nat. Acad. Sci. USA 70, 2969-2973: 2972.

Zilinskas, R.A. & Zimmermann, B.K. (eds.) (1986). The Gene-­Splicing Wars: Reflections on the Recombinant DNA Controversy.