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central dogmazentrales Dogma (ger.)

  • The basic belief originally held by molecular geneticists, that flow of genetic information can only occur from DNA to RNA to proteins. It is now known, however, that information contained within RNA molecules can also flow back to DNA, for example in the replication of retroviruses. (Oxford Dict. of Biology 2008)

    [the ›central dogma‹] once information has passed into protein, it cannot get out again. In more detail, the transfer of information from nucleic acid to nucleic acid, or from nucleic acid to protein may be possible, but transfer from protein to protein, or from protein to nucleic acid is impossible

    Crick, F.H.C. (1958). On protein synthesis. Symp. Soc. Exp. Biol. 12, 138-163: 153.