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citric acid cycleZitronensäurezyklus (ger.)

  • (Krebs's cycle, tricarboxylic-acid cycle) A cyclic series of reactions which take place in mitochondria, in the presence of oxygen. The cycle represents the principal means by which most living cells provide electrons for the generation of ATP via the electron-transport chain and oxidative phosphorylation. The sequence is initiated by the condensation of acetyl coenzyme A with oxaloacetic acid to form citric acid. This then passes through a series of reactions wherein oxaloacetic acid is reformed, and 2 moles of CO² and water and 12 moles of ATP are synthesized. (Oxford Dict. of Zoology 2009) 

    the ,,citric acid cycle“ is the preferential pathway through which carbohydrate is oxidised in animal tissues.

    Krebs, H.A. & Johnson, W.A. (1937). The role of citric acid in intermediate metabolism in animal tissues. Enzymologia 4, 148-156: 156.


    citric acid cycle

    Dixon, M. (1939). Biological oxidations and reductions. Ann. Rev. Biochem. 8, 1-36: 27


    The citric acid cycle

    Krebs, H.A. (1940). The citric acid cycle. Biochem. J. 34, 460-463.


    the reactions proposed by Krebs for the citric acid cycle.

    Foster, J.W. et al. (1941). Radioactive carbon as an indicator of carbon dioxide utilization. VII. The assimilation of carbon dioxide by molds. Proc. Nat. Acad. Sci. U.S.A. 27, 590-596: 595.